Chemotherapy best second-line choice for EGFR wild-type NSCLC By Joanna Lyford, Senior medwireNews Reporter Chemotherapy works more effectively than erlotinib as second-series therapy in people who have advanced non-small-cell lung tumor and wild-type epidermal growth element receptor genotype, a randomized controlled trial has found hydrocodone bitartrate . Hence, in the lack of a focus on oncogene, the one-size-fits-all cytotoxic method of second-line treatment of advanced NSCLC remains the best option, say the trial investigators. EGFR tyrosine kinase inhibitors such as erlotinib are currently the first selection of therapy in EGFR-mutated tumors however the role of the drugs in wild-type tumors is normally less obvious.
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