Soft Cells Fillers Soft tissue fillers are another true way to rejuvenate aging skin. As we age group, collagen decreases, leaving pores and skin sagging and wrinkly. This condition is specially common around the mouth area, nose, eyes, cheeks and brows. Soft tissue filler could be injected into epidermis to plump lips, increase hollow cheeks fullness, decrease the appearance of marks and smooth lines and wrinkles and great lines. There are several types of soft cells fillers available, with frequently occurring ones being Juviderm, Radiesse and Restylane.The companies will share equally in the responsibilities and expenditures for the development of AC220 and any extra products in the U.S. And Europe, while Astellas shall have sole responsibility to invest in development in every other territories. Under the terms of the agreement, Ambit will receive an up-front money payment of $40 million and will be permitted receive pre-commercialization payments of up to $350 million. Astellas shall have sole responsibility for funding and applying the commercialization of all products, and Ambit shall be eligible for post-approval milestone obligations upon the achievement of certain sales thresholds, in addition to tiered double-digit royalties on net product sales. In the U.S., Ambit may also have the option to co-promote AC220 and other items under a profit sharing set up where Astellas and Ambit talk about equally in revenue and losses produced from U.S.