Mean improvement in FOSQ total rating right from the start to the finish of the cross-over phase of the analysis was 1.73 – 2.50 . Significant improvements with active treatment were also seen in ESS scores, Physical Component ratings on the Short-Form 36 health study, and Total Disposition Disturbance ratings on the Profile of Disposition States level. The improvements we saw were extremely significant and clinically relevant, said Dr. Weaver. In addition, our study was executed at both smaller and large clinical practice sites, making our outcomes generalizable highly. The scholarly study had some limitations, including a brief mean duration of active daily CPAP treatment and a lower mean duration of sham daily CPAP treatment .The early renewal of this agreement through 2020 provides long-term stability for Columbia and surety of supply for Merck Serono as they turn to continue their expense in CRINONE globally. We anticipate continued positive cashflow from our primary business as Merck Serono builds further sales momentum for CRINONE. Under the terms of the amended license and offer agreement, Columbia will stay the sole supplier of CRINONE to Merck Serono and can continue steadily to sell CRINONE to Merck Serono on a nation by nation basis.