This led Dr. Zhang’s group to look for alternative approaches for targeting Chk1 in cancers therapy. Future analysis by Dr. Zhang and his team can consider two possible approaches to activating Chk1 in cancers cells artificially. One possibility is to use the gene therapy idea to provide the active mutant form of Chk1 that the group discovered, into cancers cells. The additional is to find small molecules that can induce the same conformational change of Chk1, so that they can be delivered into tumor cells to activate Chk1 molecules.Black children with serious pain are less likely to receive opioids in emergency areas than white children. A new study from George Washington University uncovered racial differences while evaluating opioid administration and pain in kids hospitalized with appendicitis. Study writer Monika Goyal, MD, MSCE, told Pharmacy Situations that pharmacists and all healthcare professionals should be aware of possible biases based on a individual’s ethnicity or race. There has been literature documenting racial disparities in the pain management of adults. Our goal was to determine whether these racial disparities also existed in the care and attention of children, Dr. Goyal stated. We specifically chose appendicitis because it is certainly a condition that’s well regarded as an agonizing surgical condition and management of pain—with opioids&mdash specifically;is one of the mainstays of treatment.