Price of Sales is likely to be around 9 percent to 10 percent of total income. R&D is likely to end up being at the top quality of 22 percent to 24 percent of total income. SG&A is likely to become at the top quality of 20 percent to 21 percent of total revenue. Taxes rate is likely to be around 26 percent to 28 percent of pretax income. GAAP diluted EPS is definitely likely to be above $4.91. Non-GAAP diluted EPS is usually expected to end up being above $5.70. Capital expenditures are anticipated to become in the number of $200 to $220 million. Biogen Idec might incur charges, realize gains or encounter other events in 2011 that might lead to actual results to change from this guidance. Recent Occasions Showcasing world-course R&D On October 26, 2011, Biogen Idec announced positive topline outcomes for CONFIRM, the next of two pivotal Stage III clinical trials made to measure the investigational oral substance BG-12 in people who have relapsing-remitting multiple sclerosis .The additional ciliopathy gene identified in this study network marketing leads to a condition known as nephronopthisis, which is connected with kidney and eye problems also. A defect in virtually any aspect of this molecular pathway may have got very similar effects at the medical level, says Dr. Vincent, who is also mind of the Center for Addiction and Mental Health’s Molecular Neuropsychiatry and Advancement Laboratory. Dr. Vincent’s group found defects in the TCTN2 gene occurring in a family group in Pakistan, where four siblings experienced Joubert syndrome. The syndrome occurs when a child inherits a defective copy of the gene from each parent. The researchers based in California led the mapping of a network of potential proteins linked to ciliopathies that interact on common pathways, as a procedure for identify the disease genes.