Ariad Ends Phase III Leukemia Drug Trial Ariad Pharmaceutics said today it’ll end its Stage III EPIC or Evaluation of Ponatinib vs. Imatinib in Chronic Myeloid Leukemia trial of Iclusig for patients with recently diagnosed CML uses of dostinex drug . The company said it and the FDA mutually agreed that the trial ought to be terminated after sufferers treated with Iclusig skilled increased blood clotting. The decision came a full week following the FDA placed a partial clinical hang on the trial, following which Ariad halted enrollment of brand-new sufferers, reduced the dosage of Iclusig to patients in the trial’s drug arm to 30 mg from 45 mg, and changed the trial’s affected person eligibility requirements to exclude sufferers with prior arterial thrombosis resulting in coronary attack or stroke.
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