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They have discovered microglia-to-neuron-signaling to be important in the development of pain hypersensitivity after injury, but also for one of the paradoxical results morphine and additional opioids sometimes produce, called hyperalgesia, which can be an increase in pain sensitivity. The identification of these important players in the advancement of chronic pain helps identify essential targets for the development of novel therapeutic avenues. Dr. Salter provided his latest results at the 9th Annual Canadian Neuroscience Achieving, on May 26th 2015 in Vancouver, British Columbia.